This study proposes a practical design approach to estimate the web-shear strength of deep prestressed hollow-core slabs (PHCS). It explores the effects of critical factors such as the shear stress distribution, biaxial tensile strength, and the reduction in effective compressive stress in concrete, quantifying their impact on web-shear strength. A data set of 85 entries is used to undertake a comparative assessment, demonstrating the improved safety and accuracy of the proposed methodology against current design provisions and previous proposals. Moreover, it is shown that neglecting the beneficial effect of the prestressing force in the transfer region leads to a conservative estimation of the web-shear strength. Furthermore, the study introduces three modified design expressions based on ACI 318-19, fib Model Code 2010, and CSA A23.3-14 standards. The proposed methodology has practical implications for enhancing the safe and cost-effective use of deep PHCS in construction practice.