Objective : The objective of current study was to evaluate variations in systolic and diastolic blood pressure and the pulse rate of normotensive and hypertensive patients going through extraction after giving two cartridges of local anesthesia with 1 : 100000 epinephrine. Study type, settings & duration : This prospective study was carried out at Department of Oral Surgery,Riphah InternationalUniversity, Islamic International Dental College (IIDH),Islamabad from January to April 2020.Methodology : Sixty patients between20-60 years of age who presented at Oral and Maxillofacial Surgery clinic for tooth extraction were included in research. Group A was hypertensive patients and Group B was normotensive patients. Theirsystolic and diastolic BP and pulse rates were documented at five different time intervals during the extraction. Independent t-test was used to check the statistical variance between mean BP and pulse rates of Group A and Group B at five different time intervals.Results : There was a significant difference in diastolic BP at T2 and T3 which means during the extraction, the diastolic blood pressure of hypertensive patients got significantly higher than normotensive patients. There was significant differencebetween diastolic blood pressure at T4 as well which signifies that diastolic BP of hypertensive patients took longer to come back to pre-anesthetic state. Difference in pulse rate remained insignificant at all time intervals. Conclusion : Local anesthesia with epinephrine doesnot significantly increase the systolic blood pressure of hypertensive patients during the extraction and but it does increase diastolic blood pressure significantly during extraction in hypertensive patients. Italsotakes longer for diastolic blood pressure of hypertensive patients to return to pre extraction state.