Offsite construction, also known as industrialized/prefabricated construction, is an alternative approach to delivering construction projects, compared to the on-site stick-built/built-on-site construction approach. Today’s offsite construction processes often use technology systems (e.g., digital design tools and automated machinery) to increase productivity and improve product quality. These systems operate collectively and rely on information generated in different operating environments. Therefore, information interoperability is critical to achieving overall construction efficiency and economics. This creates a need to study the impacts of information loss and transfer due to information interoperability, specifically for offsite construction processes. Given this, the paper uses a qualitative (case study) approach to document the offsite construction processes and the information requirements for each process. The efforts spent on information generation and transfer are taken as inputs for calculating the information loss and transfer impact using a quantitative (Monte Carlo simulation) approach. It contributes to the body of knowledge with (1) documentation of the current offsite construction processes based on wood panelized construction and the information requirements for all involved technology systems; (2) a case study approach that can be generically applied in other offsite construction companies to capture the information efficiency due to information interoperability; and (3) a generic simulation-based approach to measure the impacts of information loss and transfer between processes. As a result, the paper proposes phases of technology adoption and strategies for offsite construction companies.